Across TCGA pan-cancer cohorts, RNA activity of the Axial mesoderm development pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Axial mesoderm development pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and KIRC, show the opposite pattern, with higher activity associated with better survival.

KIRP, KIRC, and PAAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	III,IV	0.723	0.117	<.001	99	view →
KIRC	DFS	Tertile	II,III,IV	0.694	0.264	<.001	55	view →
PAAD	OS	Median	All	0.501	0.720	<.001	51	view →
UVM	DFS	Tertile	II,III,IV	0.923	0.482	<.001	49	view →
LUAD	DFS	Median	II,III,IV	0.435	0.126	.007	25	view →
CHOL	DFS	Median	All	0.131	0.676	.004	24	view →
DLBC	DFS	Median	All	0.332	0.858	.004	23	view →
SARC	DFS	Median	All	0.674	0.419	<.001	19	view →
LAML	DFS	Median	All	0.663	0.481	.008	18	view →
STAD	DFS	Median	IV	0.261	0.634	.002	17	view →
MESO	OS	Tertile	II,III,IV	0.483	0.266	.010	10	view →
THYM	DFS	Median	III,IV	1.000	0.508	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

Exploration

Same pathway, other analysis: tumor-vs-normal Axial mesoderm development activity · full GO:0048318 profile