Positive regulation of isotype switching to IgG isotypes

Across TCGA patient cohorts, RNA activity of the Positive regulation of isotype switching to IgG isotypes pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SETDB1_S1066, MCM4_S120, and TNPO3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of isotype switching to IgG isotypes activity versus SETDB1_S1066 in OV (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SETDB1_S1066 →	+0.728	+0.068	<.001	<.001	3	8
LUAD	MCM4_S120 →	+1.180	+0.062	<.001	.001	3	8
LSCC	TNPO3 →	+0.296	+0.091	<.001	<.001	3	8
LUAD	MCM6 →	+0.635	+0.068	<.001	<.001	3	8
LUAD	MCM7 →	+0.567	+0.068	<.001	<.001	3	8
UCEC	RIF1 →	+0.348	+0.066	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048304 vs SETDB1_S1066 — OV

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