Regulation of neuronal synaptic plasticity

Across TCGA patient cohorts, RNA activity of the Regulation of neuronal synaptic plasticity pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IQSEC3, SLC4A10, and LINC00643, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuronal synaptic plasticity activity versus IQSEC3 in GBM (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IQSEC3 →	+1.000	+1.640	<.001	<.001	3	6
GBM	SLC4A10 →	+1.024	+1.003	<.001	<.001	3	5
GBM	LINC00643 →	+1.663	+1.265	<.001	<.001	3	5
GBM	FXYD6 →	+1.292	+1.254	<.001	<.001	3	5
CCRCC	HRC →	+0.735	+0.550	<.001	.003	3	5
GBM	SYT16 →	+0.911	+1.139	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048168 vs IQSEC3 — GBM

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