Regulation of neuronal synaptic plasticity

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of neuronal synaptic plasticity pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 56 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Regulation of neuronal synaptic plasticity pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LGG and PAAD, show the opposite pattern, with higher activity associated with better survival.

LGG, ACC, and STAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.527	0.370	<.001	43	view →
ACC	DFS	Median	All	0.249	0.631	<.001	42	view →
STAD	DFS	Tertile	III,IV	0.295	0.594	.008	29	view →
PAAD	DFS	Median	All	0.414	0.203	.007	20	view →
HNSC	DFS	Tertile	IV	0.505	0.327	.016	19	view →
PRAD	DFS	Quartile	All	0.792	0.914	.002	16	view →
ESCA	DFS	Median	III,IV	0.552	0.340	.020	12	view →
SKCM	DFS	Tertile	III,IV	0.123	0.432	.004	12	view →
THCA	OS	Median	All	0.963	1.000	.011	11	view →
SARC	DFS	Tertile	All	0.674	0.401	.004	7	view →
DLBC	OS	Tertile	All	0.789	1.000	.016	6	view →
LAML	DFS	Quartile	All	0.654	0.459	.045	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0048168–LGG (OS)

Open the LGG breakdown →