Regulation of neuronal synaptic plasticity

Across TCGA cell cohorts, RNA activity of the Regulation of neuronal synaptic plasticity pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VMP1, CUEDC2, and MRPL51, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VMP1 grouped by Regulation of neuronal synaptic plasticity-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	VMP1 →	-1.028	-1.441	<.001	.001	3	4
BLOOD_Leukemia	CUEDC2 →	+0.701	+1.141	<.001	<.001	3	3
OVARY	MRPL51 →	+0.658	+0.968	<.001	.002	3	3
LARGE_INTESTINE	ZBTB45 →	+0.774	+1.036	.003	<.001	3	3
LARGE_INTESTINE	TAF12 →	+0.516	+0.711	.001	.005	3	3
LARGE_INTESTINE	SLAIN1 →	+2.286	+1.085	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VMP1 by Regulation of neuronal synaptic plasticity activity — KIDNEY

Explore this box plot interactively →