Regulation of neuronal synaptic plasticity

Across TCGA cell cohorts, RNA activity of the Regulation of neuronal synaptic plasticity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBX5, RC3H2, and HSDL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuronal synaptic plasticity activity versus CBX5 in BLOOD_Leukemia (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CBX5 →	+0.998	+0.785	.002	<.001	3	4
BLOOD_Leukemia	RC3H2 →	+0.710	+0.954	.001	<.001	3	4
BLOOD_Leukemia	HSDL1 →	+0.825	+0.697	.008	.005	3	4
BLOOD_Leukemia	SUDS3 →	+0.514	+0.833	.002	.001	3	4
BLOOD_Leukemia	RABGAP1 →	+0.912	+1.083	<.001	<.001	3	4
BLOOD_Leukemia	ZBTB42 →	+0.677	+0.693	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048168 vs CBX5 — BLOOD_Leukemia

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