Fused antrum stage

Across TCGA cell cohorts, RNA activity of the Fused antrum stage pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN22, DHRS7C, and MKS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPN22 grouped by Fused antrum stage-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PTPN22 →	+0.167	+0.870	.006	.004	3	4
LUNG_NSCLC_LUAD	DHRS7C →	-0.116	-1.008	.004	.008	3	4
CNS	MKS1 →	-0.310	-1.863	.005	<.001	3	4
BREAST	ARHGEF6 →	-0.149	-0.849	.007	.004	3	4
CNS	PSTK →	-0.220	-1.987	.004	.003	2	5
LARGE_INTESTINE	ZNF814 →	-0.196	-1.077	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPN22 by Fused antrum stage activity — LUNG_SCLC

Explore this box plot interactively →