Eye pigmentation

Across TCGA patient cohorts, RNA activity of the Eye pigmentation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBC1D13, TBC1D2B, and RHOG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Eye pigmentation activity versus TBC1D13 in CCRCC (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TBC1D13 →	-0.160	-0.069	.006	.001	3	5
GBM	TBC1D2B →	-0.278	-0.087	.007	<.001	3	4
COAD	RHOG →	-0.174	-0.049	.002	.002	3	4
COAD	SEC24D →	-0.253	-0.046	.001	.003	3	4
COAD	TIMM9 →	+0.219	+0.040	.004	.003	3	4
COAD	TST →	+0.324	+0.052	.009	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048069 vs TBC1D13 — CCRCC

Explore this scatter interactively →