Eye pigmentation

Across TCGA pan-cancer cohorts, RNA activity of the Eye pigmentation pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Eye pigmentation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and ACC, show the opposite pattern, with higher activity associated with better survival.

MESO, LUAD, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	II,III,IV	0.285	0.523	.003	66	view →
LUAD	OS	Median	All	0.772	0.614	.001	55	view →
ACC	DFS	Tertile	All	0.777	0.268	.001	54	view →
LGG	OS	Median	All	0.901	0.732	<.001	38	view →
STAD	DFS	Median	II,III,IV	0.683	0.363	<.001	30	view →
READ	DFS	Median	IV	0.849	0.366	.001	24	view →
TGCT	DFS	Tertile	All	0.540	0.829	.007	18	view →
KIRC	DFS	Quartile	All	0.474	0.672	.008	16	view →
SARC	DFS	Tertile	All	0.589	0.416	.006	14	view →
SKCM	DFS	Quartile	IV	0.330	0.718	.017	13	view →
LAML	DFS	Quartile	All	0.722	0.451	.028	12	view →
PRAD	DFS	Quartile	All	0.826	0.932	.009	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0048069–MESO (DFS)

Open the MESO breakdown →