Eye pigmentation

Across TCGA patient cohorts, RNA activity of the Eye pigmentation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM18, CPED1, and PODXL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Eye pigmentation activity versus RBM18 in COAD (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RBM18 →	-0.520	-0.167	.005	.002	3	3
BRCA	CPED1 →	-0.919	-0.369	<.001	.008	3	3
CCRCC	PODXL →	-0.578	-0.348	<.001	.003	3	3
LUAD	GAPT →	-0.306	-0.584	.009	.002	3	3
BRCA	SBF2 →	-0.810	-0.335	<.001	.008	3	3
BRCA	RNU4-24P →	-0.532	-0.329	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048069 vs RBM18 — COAD

Explore this scatter interactively →