Eye pigmentation

Across TCGA cell cohorts, RNA activity of the Eye pigmentation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XBP1, ARHGEF7, and QPRT, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Eye pigmentation activity versus XBP1 in SKIN (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	XBP1 →	+0.714	+0.963	.003	.001	3	1
SKIN	ARHGEF7 →	+0.456	+0.908	.002	.002	3	1
SKIN	QPRT →	+2.546	+1.212	.002	.001	3	1
SKIN	PYCARD →	+3.023	+0.820	.002	.007	3	1
SKIN	NKG7 →	-0.220	-1.215	<.001	.001	3	1
SKIN	NPTX2 →	-3.174	-1.237	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048069 vs XBP1 — SKIN

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