Embryonic eye morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic eye morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKT3-IT1, KANK2, and EDNRA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic eye morphogenesis activity versus AKT3-IT1 in UCEC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AKT3-IT1 →	+1.053	+0.434	.002	.001	3	5
UCEC	KANK2 →	+0.721	+0.328	<.001	<.001	3	5
UCEC	EDNRA →	+0.919	+0.266	<.001	.003	3	4
UCEC	CARMN →	+1.583	+0.351	<.001	.003	3	4
UCEC	CACNA1C-IT3 →	+1.480	+0.502	<.001	<.001	3	4
LSCC	AKT3 →	+0.487	+0.321	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048048 vs AKT3-IT1 — UCEC

Explore this scatter interactively →