Embryonic eye morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic eye morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTR6, UBE2L3, and ARF5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACTR6 grouped by Embryonic eye morphogenesis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ACTR6 →	+0.380	+1.345	.007	.003	3	3
STOMACH	UBE2L3 →	+0.316	+1.921	.001	<.001	3	3
CNS	ARF5 →	+0.278	+1.526	<.001	<.001	3	3
SKIN	KEAP1 →	+0.333	+1.580	.008	.001	3	2
SOFT_TISSUE	FGF18 →	+0.375	+2.425	.007	.002	3	2
OVARY	NRIP1 →	+0.284	+1.457	.008	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACTR6 by Embryonic eye morphogenesis activity — OVARY

Explore this box plot interactively →