Embryonic eye morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic eye morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPAR2, CCNT1, and ALDH1A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic eye morphogenesis activity versus LPAR2 in PANCREAS (Pearson r = 0.93).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	LPAR2 →	+2.260	+1.756	.001	<.001	3	4
LUNG_NSCLC_LUAD	CCNT1 →	-0.573	-1.024	.001	.007	3	3
LUNG_NSCLC_LUAD	ALDH1A3 →	+4.395	+1.278	.001	.007	2	4
STOMACH	BBS7 →	-0.830	-2.098	.007	<.001	2	4
SKIN	CELF6 →	+0.323	+1.313	<.001	<.001	3	3
CNS	JUP →	-2.130	-1.281	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048048 vs LPAR2 — PANCREAS

Explore this scatter interactively →