Insulin-like growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Insulin-like growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFAB1, SCNN1A, and NDUFAF4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDUFAB1 grouped by Insulin-like growth factor receptor signaling pathway-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NDUFAB1 →	-0.664	-0.316	.008	.002	3	5
BREAST	SCNN1A →	+2.409	+0.677	.002	.004	2	6
LARGE_INTESTINE	NDUFAF4 →	-0.799	-0.532	.006	.005	3	5
LARGE_INTESTINE	NTN4 →	+1.775	+0.273	.002	.006	3	5
OVARY	PRRG2 →	+1.695	+0.637	<.001	.007	3	4
LIVER	EPHA1 →	+2.632	+0.508	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDUFAB1 by Insulin-like growth factor receptor signaling pathway activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →