Insulin-like growth factor receptor signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Insulin-like growth factor receptor signaling pathway pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 51 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Insulin-like growth factor receptor signaling pathway pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and HNSC, show the opposite pattern, with higher activity associated with better survival.

KIRC, HNSC, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.735	0.548	<.001	133	view →
HNSC	DFS	Median	III,IV	0.685	0.520	.001	56	view →
BRCA	DFS	Median	III,IV	0.876	0.730	.001	48	view →
COAD	DFS	Quartile	II,III,IV	0.558	0.774	.003	38	view →
ESCA	DFS	Quartile	III,IV	0.706	0.282	.011	28	view →
DLBC	DFS	Tertile	IV	0.923	0.184	.006	17	view →
CESC	DFS	Quartile	All	0.484	0.723	.016	14	view →
OV	OS	Median	III,IV	0.268	0.364	.012	14	view →
BLCA	DFS	Quartile	All	0.198	0.580	.015	14	view →
KIRP	OS	Tertile	All	0.827	0.963	.003	13	view →
UVM	OS	Median	III,IV	0.240	0.836	.001	12	view →
UCEC	DFS	Tertile	All	0.457	0.610	.010	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0048009–KIRC (DFS)

Open the KIRC breakdown →