Regulation of lipid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of lipid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DMD, PYGM, and RFC1_S368, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipid biosynthetic process activity versus DMD in UCEC (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DMD →	+1.160	+0.296	<.001	<.001	3	8
UCEC	PYGM →	+1.132	+0.285	<.001	<.001	3	7
UCEC	RFC1_S368 →	-0.875	-0.207	<.001	.001	2	7
UCEC	SMC4 →	-0.674	-0.272	<.001	<.001	3	6
UCEC	FHL1 →	+1.458	+0.253	<.001	<.001	3	6
UCEC	ILK →	+0.825	+0.273	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046890 vs DMD — UCEC

Explore this scatter interactively →