Quinolinate metabolic process

Across TCGA patient cohorts, RNA activity of the Quinolinate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are QPRT, CTSA, and LSP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Quinolinate metabolic process activity versus QPRT in BRCA (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	QPRT →	+0.778	+0.108	<.001	<.001	3	9
LSCC	CTSA →	+0.352	+0.123	<.001	<.001	3	7
GBM	LSP1 →	+0.810	+0.088	<.001	.006	3	7
GBM	WAS →	+0.746	+0.119	<.001	<.001	3	7
GBM	WIPF1 →	+0.407	+0.109	<.001	<.001	3	7
GBM	NCKAP1L →	+0.611	+0.100	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046874 vs QPRT — BRCA

Explore this scatter interactively →