Isoprenoid transport

Across TCGA patient cohorts, RNA activity of the Isoprenoid transport pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSPA12B, RFC1_S368, and RRM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isoprenoid transport activity versus HSPA12B in PDAC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HSPA12B →	+0.412	+0.110	<.001	<.001	3	6
UCEC	RFC1_S368 →	-0.691	-0.119	<.001	<.001	3	5
COAD	RRM1 →	-0.448	-0.080	<.001	<.001	3	5
PDAC	TK1 →	-0.623	-0.121	<.001	<.001	3	5
COAD	ABCB1 →	+0.630	+0.090	<.001	.001	3	5
UCEC	FARP1 →	+0.311	+0.097	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046864 vs HSPA12B — PDAC

Explore this scatter interactively →