Isoprenoid transport

Across TCGA patient cohorts, RNA activity of the Isoprenoid transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFKB2, SFTA2, and HPN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isoprenoid transport activity versus NFKB2 in UCEC (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NFKB2 →	-0.559	-0.734	.005	.001	3	4
COAD	SFTA2 →	+1.716	+0.616	<.001	.002	3	3
CCRCC	HPN →	+0.703	+0.356	.002	.005	2	4
CCRCC	RNU105C →	-0.181	-0.425	.006	.005	3	3
CCRCC	HPN-AS1 →	+0.599	+0.401	.002	.007	2	4
GBM	SESN1 →	+0.693	+0.809	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046864 vs NFKB2 — UCEC

Explore this scatter interactively →