Isoprenoid transport

Across TCGA cell cohorts, RNA activity of the Isoprenoid transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCIRG1, WBP2, and GLRX, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TCIRG1 grouped by Isoprenoid transport-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TCIRG1 →	+2.251	+0.531	.003	.005	3	4
BLOOD_Lymphoma	WBP2 →	-0.809	-1.816	.005	.001	3	4
OVARY	GLRX →	+1.804	+1.093	.001	.001	3	4
OVARY	CREG2 →	+1.495	+0.888	<.001	.002	3	4
OVARY	LACC1 →	+0.820	+1.175	.002	<.001	3	4
OVARY	DDX60L →	+1.504	+0.886	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TCIRG1 by Isoprenoid transport activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →