Negative regulation of protein export from nucleus

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein export from nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRM2, SMC4, and MCM6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein export from nucleus activity versus RRM2 in UCEC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RRM2 →	+0.649	+0.062	.004	<.001	3	8
OV	SMC4 →	+0.608	+0.051	<.001	<.001	3	7
OV	MCM6 →	+0.714	+0.045	.002	.001	3	7
LUAD	MCM7 →	+0.531	+0.051	<.001	<.001	3	7
OV	SMC2 →	+0.600	+0.049	<.001	<.001	3	7
COAD	MCM2 →	+0.541	+0.048	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046826 vs RRM2 — UCEC

Explore this scatter interactively →