Microtubule polymerization

Across TCGA cell cohorts, RNA activity of the Microtubule polymerization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTGES3L, B4GALT3, and NDST2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTGES3L grouped by Microtubule polymerization-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PTGES3L →	+0.669	+0.143	.007	.002	3	4
OVARY	B4GALT3 →	-0.485	-0.190	<.001	<.001	3	4
BLOOD_Myeloma	NDST2 →	-0.973	-0.449	.008	.006	3	4
URINARY_TRACT	ING5 →	-1.011	-0.172	.002	<.001	3	4
LUNG_SCLC	SEH1L →	+0.553	+0.190	.001	.002	2	5
PANCREAS	LSM11 →	-0.395	-0.142	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTGES3L by Microtubule polymerization activity — BREAST

Explore this box plot interactively →