Microtubule polymerization

Across TCGA pan-cancer cohorts, RNA activity of the Microtubule polymerization pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 95 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Microtubule polymerization pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and BRCA, show the opposite pattern, with higher activity associated with better survival.

ACC, KIRC, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.306	0.802	<.001	133	view →
KIRC	DFS	Tertile	All	0.506	0.734	<.001	104	view →
UVM	DFS	Median	All	0.325	0.635	<.001	88	view →
MESO	OS	Median	All	0.273	0.454	.004	85	view →
KICH	OS	Tertile	All	0.683	1.000	.001	60	view →
LGG	DFS	Median	All	0.635	0.812	<.001	53	view →
LIHC	OS	Median	All	0.697	0.827	<.001	52	view →
HNSC	DFS	Tertile	IV	0.584	0.359	.009	51	view →
BRCA	OS	Tertile	III,IV	0.990	0.839	<.001	36	view →
KIRP	OS	Tertile	All	0.429	0.769	<.001	35	view →
LUAD	OS	Tertile	All	0.763	0.880	<.001	30	view →
BLCA	DFS	Tertile	All	0.452	0.662	.014	25	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0046785–ACC (DFS)

Open the ACC breakdown →