Response to cadmium ion

Across TCGA patient cohorts, RNA activity of the Response to cadmium ion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC1A2, ZNF396, and MSN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to cadmium ion activity versus SLC1A2 in BRCA (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC1A2 →	-1.044	-0.255	<.001	<.001	3	5
BRCA	ZNF396 →	-0.621	-0.188	<.001	<.001	3	5
BRCA	MSN →	+0.720	+0.274	<.001	<.001	3	5
UCEC	GAS2 →	-0.635	-0.137	.005	.008	3	5
HNSC	SVIP →	-0.931	-0.164	<.001	<.001	3	5
LSCC	TSGA10 →	-0.569	-0.224	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046686 vs SLC1A2 — BRCA

Explore this scatter interactively →