Response to cadmium ion

Across TCGA pan-cancer cohorts, RNA activity of the Response to cadmium ion pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 59 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Response to cadmium ion pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and ESCA, show the opposite pattern, with higher activity associated with better survival.

ACC, KICH, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Quartile	All	0.219	0.738	<.001	69	view →
KICH	DFS	Quartile	II,III,IV	0.094	0.931	<.001	68	view →
UVM	OS	Median	III,IV	0.411	0.858	.008	44	view →
KIRC	DFS	Quartile	All	0.481	0.698	<.001	34	view →
KIRP	OS	Tertile	All	0.503	0.778	.002	34	view →
OV	DFS	Quartile	III,IV	0.305	0.418	.015	28	view →
SKCM	DFS	Tertile	II,III,IV	0.770	0.617	.013	24	view →
THCA	OS	Median	II,III,IV	0.836	0.979	.005	23	view →
ESCA	OS	Quartile	III,IV	0.681	0.292	.021	22	view →
UCEC	DFS	Quartile	IV	0.723	0.276	.005	22	view →
MESO	OS	Median	II,III,IV	0.231	0.639	.014	15	view →
LUAD	DFS	Median	IV	0.753	0.306	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0046686–ACC (DFS)

Open the ACC breakdown →