Response to cadmium ion

Across TCGA cell cohorts, RNA activity of the Response to cadmium ion pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDHX, TMEM217, and MRPS16, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to cadmium ion activity versus PDHX in CNS (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PDHX →	+0.811	+0.241	.003	.005	3	6
OVARY	TMEM217 →	-1.068	-0.334	<.001	<.001	3	6
LARGE_INTESTINE	MRPS16 →	+0.435	+0.169	.004	.004	2	7
BLOOD_Lymphoma	WASF1 →	+2.471	+0.303	<.001	<.001	3	5
BLOOD_Lymphoma	RASSF2 →	+3.378	+0.372	<.001	<.001	3	5
BLOOD_Lymphoma	SUPV3L1 →	+0.753	+0.328	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046686 vs PDHX — CNS

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