Positive regulation of alpha-beta T cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of alpha-beta T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-A, HLA-B, and B2M, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of alpha-beta T cell proliferation activity versus HLA-A in BREAST (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HLA-A →	+3.730	+1.060	<.001	.002	3	7
LUNG_SCLC	HLA-B →	+6.321	+1.704	<.001	<.001	3	6
LUNG_SCLC	B2M →	+2.348	+1.829	<.001	<.001	3	6
LUNG_SCLC	TAP1 →	+3.461	+1.285	<.001	.005	3	5
OESOPHAGUS	AUTS2 →	-1.743	-0.231	.006	.005	3	5
OVARY	TGFB3 →	-1.781	-0.868	.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046641 vs HLA-A — BREAST

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