Xenobiotic export from cell

Across TCGA cell cohorts, RNA activity of the Xenobiotic export from cell pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP3K2, CEP20, and FOXD4L3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xenobiotic export from cell activity versus MAP3K2 in LARGE_INTESTINE (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAP3K2 →	-0.750	-1.671	.001	<.001	3	2
LUNG_NSCLC_LUAD	CEP20 →	-1.322	-1.885	.003	<.001	3	2
LUNG_NSCLC_LUAD	FOXD4L3 →	+0.086	+1.185	.005	.004	3	2
LUNG_NSCLC_LUAD	PIGBOS1 →	-0.709	-1.108	.006	.009	3	2
BREAST	HAS3 →	+4.030	+1.960	<.001	<.001	3	2
BREAST	MICU1 →	+1.566	+1.960	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046618 vs MAP3K2 — LARGE_INTESTINE

Explore this scatter interactively →