Q-omics provides the consensus-scored PIGBOS1 profile across patient tissues and cancer cell-line models. PIGBOS1 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in STAD. Among the 18 cancer types available for tumor–normal comparison, PIGBOS1 is differentially expressed in 11, with the highest sampling consensus in LIHC. Additionally, PIGBOS1 RNA expression shows 18,692 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight STAD, LIHC, and ACC as cancer lineages where PIGBOS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PIGBOS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PIGBOS1 survival associations across molecular data types. PIGBOS1 RNA expression shows survival associations in the most cancer types (23), followed by mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PIGBOS1 RNA expression–survival associations across cancer types. High PIGBOS1 expression shows unfavorable associations in STAD, UVM, KICH, ACC, KIRC and ESCA. The STAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify STAD as the clearest survival context for PIGBOS1 RNA expression.
This table summarizes PIGBOS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 2. The strongest signals are observed in LIHC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for PIGBOS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PIGBOS1 shows lower tumor expression in KICH, UCEC and THCA and higher tumor expression in LIHC, HNSC and STAD. The LIHC box plot shows higher PIGBOS1 RNA expression in tumor versus normal tissue (log2 FC = +0.827, t-test p < 0.001).
This table shows molecular features associated with PIGBOS1 in patient tissues and cancer cell lines. In patient samples, PIGBOS1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, PIGBOS1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Leukemia, while CRISPR and shRNA rows add functional-dependency signals in BREAST.
