Negative regulation of centriole replication

Across TCGA patient cohorts, RNA activity of the Negative regulation of centriole replication pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRRC2C, SP2, and SF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of centriole replication activity versus PRRC2C in GBM (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRRC2C →	+0.218	+0.207	.002	.002	3	4
LSCC	SP2 →	+0.348	+0.257	<.001	.001	3	4
LSCC	SF1 →	+0.245	+0.225	.003	.005	3	4
CCRCC	NDFIP2-AS1 →	-0.069	-0.583	<.001	<.001	3	3
LSCC	MSTO2P →	+0.490	+0.355	.005	.004	3	3
LSCC	POLG2 →	+0.341	+0.435	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046600 vs PRRC2C — GBM

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