Regulation of centriole replication

Across TCGA patient cohorts, RNA activity of the Regulation of centriole replication pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HAT1, NCAPG_S674, and NPM1_S254, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of centriole replication activity versus HAT1 in OV (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HAT1 →	+0.500	+0.047	<.001	.005	3	10
LUAD	NCAPG_S674 →	+1.130	+0.069	<.001	<.001	3	10
BRCA	NPM1_S254 →	+1.175	+0.036	<.001	.001	3	10
LUAD	RRM2 →	+0.877	+0.075	<.001	<.001	3	9
LUAD	SMC4 →	+0.625	+0.072	<.001	<.001	3	9
LSCC	TFDP1_S23 →	+0.711	+0.054	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046599 vs HAT1 — OV

Explore this scatter interactively →