Regulation of centriole replication

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of centriole replication pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 23 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Regulation of centriole replication pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and HNSC, show the opposite pattern, with higher activity associated with better survival.

MESO, ACC, and KICH are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.399	0.668	<.001	112	view →
ACC	DFS	Median	All	0.276	0.799	<.001	108	view →
KICH	DFS	Quartile	All	0.486	1.000	<.001	101	view →
KIRC	DFS	Tertile	II,III,IV	0.329	0.639	<.001	82	view →
LIHC	DFS	Median	All	0.438	0.640	<.001	71	view →
LGG	OS	Median	All	0.696	0.902	<.001	54	view →
KIRP	OS	Median	All	0.587	0.768	<.001	45	view →
READ	OS	Tertile	II,III,IV	0.914	0.294	<.001	45	view →
HNSC	OS	Median	IV	0.495	0.331	.009	43	view →
UCS	OS	Median	II,III,IV	0.607	0.260	.017	28	view →
THCA	DFS	Tertile	All	0.822	0.945	<.001	28	view →
PCPG	OS	Quartile	All	0.631	1.000	.001	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0046599–MESO (OS)

Open the MESO breakdown →