Regulation of centriole replication

Across TCGA patient cohorts, RNA activity of the Regulation of centriole replication pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMNB1, CLSPN, and PLK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of centriole replication activity versus LMNB1 in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LMNB1 →	+0.530	+0.475	.001	.002	3	5
OV	CLSPN →	+0.954	+0.587	<.001	.004	3	5
BRCA	PLK1 →	+0.584	+0.453	<.001	.004	3	5
BRCA	TBC1D31 →	+0.521	+0.663	<.001	<.001	3	4
PDAC	UBQLN4P1 →	+0.134	+0.564	<.001	.006	3	4
CCRCC	KIF20A →	+0.620	+0.528	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046599 vs LMNB1 — BRCA

Explore this scatter interactively →