Regulation of centriole replication

Across TCGA cell cohorts, RNA activity of the Regulation of centriole replication pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAOK3, SQOR, and NXPE3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAOK3 grouped by Regulation of centriole replication-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TAOK3 →	+1.119	+0.273	.001	<.001	3	4
STOMACH	SQOR →	+2.776	+0.181	.001	.005	3	4
STOMACH	NXPE3 →	-1.687	-0.375	<.001	.001	3	4
STOMACH	ANKRD22 →	+2.685	+0.269	.001	.001	3	4
PANCREAS	MMP15 →	+1.469	+0.283	<.001	<.001	3	4
BREAST	ARFGEF1 →	+1.044	+0.337	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAOK3 by Regulation of centriole replication activity — STOMACH

Explore this box plot interactively →