Glycerophospholipid catabolic process

Across TCGA patient cohorts, RNA activity of the Glycerophospholipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR4537, RPL12P15, and CCL8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycerophospholipid catabolic process activity versus MIR4537 in UCEC (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4537 →	-0.725	-0.122	.002	.008	3	3
LUAD	RPL12P15 →	-0.458	-0.224	<.001	.002	3	3
GBM	CCL8 →	+1.101	+0.198	.003	.009	3	3
GBM	KCNK1 →	+1.403	+0.265	<.001	<.001	3	3
GBM	PCSK6 →	+1.389	+0.292	<.001	<.001	3	3
GBM	FCGR1A →	+0.609	+0.207	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046475 vs MIR4537 — UCEC

Explore this scatter interactively →