Glycerophospholipid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Glycerophospholipid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL21, RPL5, and SERBP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycerophospholipid biosynthetic process activity versus RPL21 in LUAD (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL21 →	-0.231	-0.026	.003	<.001	3	8
CCRCC	RPL5 →	-0.247	-0.034	<.001	<.001	3	8
GBM	SERBP1 →	-0.245	-0.037	<.001	<.001	3	8
GBM	RPL4 →	-0.293	-0.026	.003	.001	3	7
CCRCC	RPS2 →	-0.194	-0.023	.006	<.001	3	7
GBM	SEPTIN4 →	+0.527	+0.022	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046474 vs RPL21 — LUAD

Explore this scatter interactively →