Glycerophospholipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Glycerophospholipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF35, DOCK7, and SLC9A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF35 grouped by Glycerophospholipid biosynthetic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ZNF35 →	-0.478	-1.138	.002	.007	3	4
SOFT_TISSUE	DOCK7 →	-0.624	-1.077	.009	.002	3	4
OESOPHAGUS	SLC9A2 →	+1.067	+1.049	.004	.003	3	3
BREAST	FAM126A →	-1.668	-0.937	.006	<.001	3	3
OESOPHAGUS	TMEM63C →	-1.748	-1.063	<.001	.004	3	3
OESOPHAGUS	MGAT5B →	-1.548	-0.985	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF35 by Glycerophospholipid biosynthetic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →