Phosphatidic acid metabolic process

Across TCGA patient cohorts, RNA activity of the Phosphatidic acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF4H, SORBS1, and ALDH1A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidic acid metabolic process activity versus EIF4H in OV (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EIF4H →	-0.250	-0.040	.007	.006	3	5
BRCA	SORBS1 →	+0.433	+0.022	.001	.003	3	5
HNSC	ALDH1A1 →	+0.719	+0.052	.001	.001	3	5
LSCC	MAP1A →	+0.397	+0.031	.003	.009	3	5
LSCC	MAP1A_S1069 →	+0.762	+0.032	<.001	.001	3	5
LSCC	MAP1B →	+0.877	+0.036	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046473 vs EIF4H — OV

Explore this scatter interactively →