Monoacylglycerol metabolic process

Across TCGA patient cohorts, RNA activity of the Monoacylglycerol metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AHCYL2, LSM3, and PLA2G4A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monoacylglycerol metabolic process activity versus AHCYL2 in LSCC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AHCYL2 →	+0.253	+0.051	.009	.003	3	7
CCRCC	LSM3 →	-0.128	-0.085	<.001	<.001	3	6
UCEC	PLA2G4A →	+0.602	+0.073	<.001	.001	3	6
GBM	RFC4 →	-0.385	-0.087	.002	.001	3	6
LUAD	RFC1 →	-0.342	-0.091	<.001	<.001	3	6
GBM	USP39 →	-0.241	-0.082	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046462 vs AHCYL2 — LSCC

Explore this scatter interactively →