Monoacylglycerol metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Monoacylglycerol metabolic process pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 14 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Monoacylglycerol metabolic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as MESO and KICH, show the opposite pattern, with higher activity associated with better survival.

UVM, MESO, and KICH are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.429	0.731	.001	95	view →
MESO	OS	Tertile	All	0.466	0.242	.004	77	view →
KICH	DFS	Median	III,IV	0.914	0.269	<.001	49	view →
KIRP	DFS	Median	III,IV	0.876	0.561	.003	48	view →
LAML	DFS	Tertile	All	0.240	0.580	<.001	40	view →
HNSC	DFS	Median	II,III,IV	0.734	0.640	.010	31	view →
LIHC	OS	Quartile	II,III,IV	0.774	0.465	.013	24	view →
PAAD	OS	Median	All	0.716	0.469	.001	16	view →
UCS	OS	Median	II,III,IV	0.613	0.255	.013	16	view →
ESCA	OS	Quartile	All	0.522	1.000	.020	15	view →
STAD	DFS	Tertile	II,III,IV	0.691	0.498	.010	14	view →
PRAD	DFS	Median	All	0.900	0.956	.001	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0046462–UVM (DFS)

Open the UVM breakdown →