Short-chain fatty acid metabolic process

Across TCGA patient cohorts, RNA activity of the Short-chain fatty acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PCCB, TOM1L1, and DCAF11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Short-chain fatty acid metabolic process activity versus PCCB in BRCA (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PCCB →	+0.374	+0.047	<.001	<.001	3	6
BRCA	TOM1L1 →	+0.613	+0.062	<.001	<.001	3	6
LSCC	DCAF11 →	+0.285	+0.049	<.001	<.001	3	6
BRCA	HSPA13 →	-0.448	-0.055	<.001	<.001	3	6
BRCA	ACAD8 →	+0.418	+0.053	<.001	<.001	3	6
BRCA	AUH →	+0.459	+0.075	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046459 vs PCCB — BRCA

Explore this scatter interactively →