Short-chain fatty acid metabolic process

Across TCGA patient cohorts, RNA activity of the Short-chain fatty acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHYH, CD101, and KBTBD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Short-chain fatty acid metabolic process activity versus PHYH in OV (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PHYH →	+0.690	+0.177	.002	.003	3	6
GBM	CD101 →	-0.646	-0.123	.009	.004	3	4
LSCC	KBTBD2 →	-0.274	-0.124	.007	.002	3	4
CCRCC	HAUS2 →	-0.212	-0.135	<.001	<.001	3	4
PDAC	TMX3 →	-0.290	-0.118	<.001	.009	3	4
PDAC	DCP2 →	-0.173	-0.111	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046459 vs PHYH — OV

Explore this scatter interactively →