Organophosphate catabolic process

Across TCGA patient cohorts, RNA activity of the Organophosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTK, RO60, and CBX3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organophosphate catabolic process activity versus TTK in PDAC (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TTK →	-0.401	-0.097	.002	.002	3	5
HNSC	RO60 →	-0.603	-0.172	.008	.002	3	4
PDAC	CBX3 →	-0.402	-0.145	<.001	.002	3	4
PDAC	TOP2A →	-0.481	-0.110	.002	<.001	2	5
PDAC	FBXO28 →	-0.391	-0.161	<.001	<.001	3	4
PDAC	CENPH →	-0.369	-0.133	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046434 vs TTK — PDAC

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