Organophosphate catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Organophosphate catabolic process pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 146 member genes.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher Organophosphate catabolic process pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and HNSC, show the opposite pattern, with higher activity associated with better survival.

SKCM, HNSC, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Tertile	All	0.284	0.150	<.001	62	view →
HNSC	DFS	Median	III,IV	0.344	0.255	.013	43	view →
BRCA	OS	Tertile	III,IV	0.690	0.370	<.001	43	view →
LAML	DFS	Tertile	All	0.256	0.526	.001	36	view →
BLCA	OS	Tertile	All	0.824	0.668	.002	26	view →
KIRC	DFS	Tertile	All	0.558	0.699	.004	24	view →
PAAD	DFS	Median	II,III,IV	0.626	0.369	.006	22	view →
READ	DFS	Median	All	0.959	0.389	<.001	21	view →
LGG	OS	Quartile	All	0.679	0.935	<.001	16	view →
LIHC	OS	Tertile	II,III,IV	0.497	0.679	.004	16	view →
ACC	DFS	Median	IV	0.038	0.407	<.001	15	view →
CESC	DFS	Median	All	0.674	0.802	.011	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0046434–SKCM (DFS)

Open the SKCM breakdown →