Negative regulation of receptor signaling pathway via JAK-STAT

Across TCGA patient cohorts, RNA activity of the Negative regulation of receptor signaling pathway via JAK-STAT pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPN1, DOCK8-AS1, and TYMP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of receptor signaling pathway via JAK-STAT activity versus GPN1 in COAD (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GPN1 →	+0.310	+0.191	.003	.002	3	4
GBM	DOCK8-AS1 →	+0.412	+0.377	<.001	<.001	3	4
GBM	TYMP →	+0.881	+0.358	<.001	.002	3	4
GBM	KLHDC2 →	-0.400	-0.346	<.001	<.001	3	4
GBM	NKX3-1 →	+0.480	+0.353	.001	<.001	3	4
GBM	C5orf58 →	+0.530	+0.352	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046426 vs GPN1 — COAD

Explore this scatter interactively →