Negative regulation of receptor signaling pathway via JAK-STAT

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of receptor signaling pathway via JAK-STAT pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 23 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Negative regulation of receptor signaling pathway via JAK-STAT pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and HNSC, show the opposite pattern, with higher activity associated with better survival.

KIRP, KIRC, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	All	0.637	0.884	<.001	86	view →
KIRC	DFS	Median	II,III,IV	0.414	0.604	.003	76	view →
SKCM	OS	Median	II,III,IV	0.487	0.240	.001	69	view →
HNSC	DFS	Tertile	III,IV	0.471	0.241	<.001	56	view →
LGG	OS	Median	All	0.692	0.893	<.001	54	view →
MESO	OS	Tertile	II,III,IV	0.721	0.401	.009	39	view →
ACC	DFS	Median	II,III,IV	0.383	0.752	.003	24	view →
UVM	DFS	Tertile	III,IV	0.283	0.856	.007	19	view →
UCS	OS	Quartile	II,III,IV	0.704	0.310	.017	16	view →
LUAD	DFS	Tertile	All	0.796	0.635	.016	12	view →
GBM	OS	Tertile	All	0.343	0.497	.024	9	view →
UCEC	OS	Quartile	All	0.887	0.943	.005	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0046426–KIRP (OS)

Open the KIRP breakdown →