Negative regulation of receptor signaling pathway via JAK-STAT

Across TCGA cell cohorts, RNA activity of the Negative regulation of receptor signaling pathway via JAK-STAT pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NME7, DUSP5, and AFAP1L1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of receptor signaling pathway via JAK-STAT activity versus NME7 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NME7 →	+1.188	+0.432	.003	.002	3	5
BONE	DUSP5 →	+1.657	+0.491	.004	.006	3	5
STOMACH	AFAP1L1 →	+1.524	+1.128	.009	.006	3	5
STOMACH	TTC7B →	+2.869	+1.434	<.001	<.001	3	5
PANCREAS	DLX1 →	+1.488	+0.255	.002	.003	3	5
PANCREAS	SLIT2 →	+1.363	+0.248	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046426 vs NME7 — UPPER_AERODIGESTIVE_TRACT

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