Urate metabolic process

Across TCGA patient cohorts, RNA activity of the Urate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARMIL1, ADGRF1, and SLC35F2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Urate metabolic process activity versus CARMIL1 in GBM (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CARMIL1 →	+0.935	+0.716	<.001	<.001	3	7
OV	ADGRF1 →	+0.847	+0.919	.001	.001	3	5
UCEC	SLC35F2 →	+0.839	+0.429	.008	.004	2	4
OV	STX19 →	+1.115	+0.920	.009	.002	3	3
GBM	KCNH1-IT1 →	-0.799	-0.683	<.001	.001	3	3
GBM	ITPRID2 →	+0.526	+0.903	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046415 vs CARMIL1 — GBM

Explore this scatter interactively →