Urate metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Urate metabolic process pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 12 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Urate metabolic process pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and KIRP, show the opposite pattern, with higher activity associated with better survival.

KIRC, KIRP, and COAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.749	0.524	<.001	169	view →
KIRP	DFS	Tertile	III,IV	0.645	0.103	<.001	103	view →
COAD	DFS	Tertile	All	0.594	0.363	<.001	57	view →
OV	OS	Median	II,III,IV	0.373	0.272	.001	44	view →
LUSC	OS	Tertile	II,III,IV	0.598	0.348	.001	35	view →
GBM	OS	Median	All	0.497	0.326	<.001	34	view →
BLCA	DFS	Quartile	All	0.408	0.550	.008	30	view →
ACC	OS	Quartile	All	1.000	0.365	.002	29	view →
HNSC	OS	Median	IV	0.651	0.754	.007	26	view →
KICH	DFS	Median	II,III,IV	1.000	0.733	.011	20	view →
PRAD	DFS	Tertile	All	0.899	0.730	<.001	16	view →
PAAD	OS	Tertile	All	0.359	0.544	.019	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0046415–KIRC (OS)

Open the KIRC breakdown →